Function and Biology Details
Reaction catalysed:
A 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD(P)(+) = a 3-oxosteroid + CO(2) + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172386 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
Molecule details ›
Chains: A, B
Length: 245 amino acids
Theoretical weight: 27.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: 3-beta hydroxysteroid dehydrogenase/isomerase family
Length: 245 amino acids
Theoretical weight: 27.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q15738 (Residues: 31-267; Coverage: 64%)
Sequence domains: 3-beta hydroxysteroid dehydrogenase/isomerase family
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
PAL/PLS BEAMLINE 11C
Spacegroup:
P21
Expression system: Escherichia coli
