Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-243172 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ubiquitin carboxyl-terminal hydrolase 46
Molecule details ›
Chain: A
Length: 352 amino acids
Theoretical weight: 41.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin carboxyl-terminal hydrolase
Length: 352 amino acids
Theoretical weight: 41.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P62068 (Residues: 23-366; Coverage: 94%)
Sequence domains: Ubiquitin carboxyl-terminal hydrolase
WD repeat-containing protein 48
Molecule details ›
Chain: B
Length: 620 amino acids
Theoretical weight: 69.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 620 amino acids
Theoretical weight: 69.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q8TAF3 (Residues: 1-580; Coverage: 86%)
Sequence domains:
WD repeat-containing protein 20
Molecule details ›
Chain: C
Length: 444 amino acids
Theoretical weight: 48.56 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
Sequence domains: WD domain, G-beta repeat
Length: 444 amino acids
Theoretical weight: 48.56 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
- Canonical: L8I535 (Residues: 1-304, 389-420, 535-595; Coverage: 62%)
- Canonical: Q8TBZ3 (Residues: 279-318; Coverage: 7%)
Sequence domains: WD domain, G-beta repeat
