› 6jm5

X-ray diffraction
1.6Å resolution

Crystal structure of TBC1D23 C terminal domain

Released:
DOI: 10.2210/pdb6jm5/pdb
PDB entry 6jm5 coloured by chain, front view.
PDB entry 6jm5 coloured by chain, side view.
PDB entry 6jm5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH.
Huang W, Liu Z, Yang F, Zhou H, Yong X, Yang X, Zhou Y, Xue L, Zhang Y, Liu D, Meng W, Zhang W, Zhang X, Shen X, Sun Q, Li L, Ma C, Wei Y, Billadeau DD, Mo X, Jia D
Proc Natl Acad Sci U S A 116 22598-22608 (2019)
PMID: 31624125

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192626 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TBC1 domain family member 23 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 13.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NUY8 (Residues: 577-699; Coverage: 18%)
Gene names: NS4ATP1, TBC1D23
Sequence domains: TBC1 domain family member 23 C-terminal

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 130.822Å b: 48.95Å c: 47.439Å
α: 90° β: 109.64° γ: 90°
R-values:
R R work R free
0.159 0.157 0.207
Expression system: Escherichia coli

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Citations

3 review citations

Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions.
Tu et al. (2020)
2 more

2 mentions without citation

Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH.
Huang et al. (2019)
1 more