› 6jmr

Electron Microscopy
4.1Å resolution

CD98hc extracellular domain bound to HBJ127 Fab and MEM-108 Fab

Released:
DOI: 10.2210/pdb6jmr/pdb
PDB entry 6jmr coloured by chain, front view.
PDB entry 6jmr coloured by chain, side view.
PDB entry 6jmr coloured by chain, top view.
Source organisms:
Primary publication:
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc.
Lee Y, Wiriyasermkul P, Jin C, Quan L, Ohgaki R, Okuda S, Kusakizako T, Nishizawa T, Oda K, Ishitani R, Yokoyama T, Nakane T, Shirouzu M, Endou H, Nagamori S, Kanai Y, Nureki O
Nat Struct Mol Biol 26 510-517 (2019)
PMID: 31160781
Related structures: EMD-9850

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209356 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
Antibody Chain: E
Molecule details ›
Chain: E
Length: 220 amino acids
Theoretical weight: 23.83 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Antibody Chain: F
Molecule details ›
Chain: F
Length: 218 amino acids
Theoretical weight: 24.11 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Amino acid transporter heavy chain SLC3A2 Chain: B
Antibody Chain: C
Antibody Chain: D

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 4.1Å
Relevant EMDB volumes: EMD-9850
Expression systems:
  • Mus musculus
  • Homo sapiens

Quick links

Citations

25 review citations

The solute carrier transporters and the brain: Physiological and pharmacological implications.
Hu et al. (2020)
24 more

2 mentions without citation

The Ectodomains of rBAT and 4F2hc Are Fake or Orphan α-Glucosidases.
Fort et al. (2021)
1 more