› 6jo7

X-ray diffraction
2.4Å resolution

Crystal structure of mouse MXRA8

Released:
DOI: 10.2210/pdb6jo7/pdb
PDB entry 6jo7 coloured by chain, front view.
PDB entry 6jo7 coloured by chain, side view.
PDB entry 6jo7 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein.
Song H, Zhao Z, Chai Y, Jin X, Li C, Yuan F, Liu S, Gao Z, Wang H, Song J, Vazquez L, Zhang Y, Tan S, Morel CM, Yan J, Shi Y, Qi J, Gao F, Gao GF
Cell 177 1714-1724.e12 (2019)
PMID: 31080063

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190093 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix remodeling-associated protein 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 270 amino acids
Theoretical weight: 30.72 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9DBV4 (Residues: 23-291; Coverage: 64%)
Gene names: Asp3, Dicam, Mxra8
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: I222
Unit cell:
a: 72.446Å b: 143.486Å c: 196.346Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.219 0.245
Expression system: Escherichia coli BL21

Quick links

Citations

15 review citations

A molecular understanding of alphavirus entry.
Holmes et al. (2020)
14 more

1 mention without citation

The CD147 Protein Complex Is Involved in Entry of Chikungunya Virus and Related Alphaviruses in Human Cells.
De Caluwé et al. (2021)