› 6jpt

X-ray diffraction
0.96Å resolution

Crystal structure of human PAC3 homodimer (trigonal form)

Released:
DOI: 10.2210/pdb6jpt/pdb
PDB entry 6jpt coloured by chain, front view.
PDB entry 6jpt coloured by chain, side view.
PDB entry 6jpt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular and Structural Basis of the Proteasome α Subunit Assembly Mechanism Mediated by the Proteasome-Assembling Chaperone PAC3-PAC4 Heterodimer.
Satoh T, Yagi-Utsumi M, Okamoto K, Kurimoto E, Tanaka K, Kato K
Int J Mol Sci 20 (2019)
PMID: 31067643

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proteasome assembly chaperone 3 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BT73 (Residues: 1-122; Coverage: 100%)
Gene names: C7orf48, PAC3, PSMG3
Sequence domains: Proteasome assembly chaperone 3
Structure domains: Ribosomal Protein S5; domain 2

Ligands and Environments

2 bound ligands:
Ligand SCN 1 x SCN
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P3121
Unit cell:
a: 71.229Å b: 71.229Å c: 47.074Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.136 0.136 0.146
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The Molecular Mechanisms Governing the Assembly of the Immuno- and Thymoproteasomes in the Presence of Constitutive Proteasomes.
Watanabe et al. (2022)
8 other articles

1 mention without citation

Molecular and Structural Basis of the Proteasome α Subunit Assembly Mechanism Mediated by the Proteasome-Assembling Chaperone PAC3-PAC4 Heterodimer.
Satoh et al. (2019)