6jt0

Electron Microscopy
4Å resolution

Structure of human soluble guanylate cyclase in the unliganded state

Released:
Source organism: Homo sapiens
Primary publication:
Structural insights into the mechanism of human soluble guanylate cyclase.
Nature 574 206-210 (2019)
PMID: 31514202
Related structures: EMD-9883

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-169668 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Guanylate cyclase soluble subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 690 amino acids
Theoretical weight: 77.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02108 (Residues: 1-690; Coverage: 100%)
Gene names: GUC1A3, GUCSA3, GUCY1A1, GUCY1A3
Sequence domains:
Guanylate cyclase soluble subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 619 amino acids
Theoretical weight: 70.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02153 (Residues: 1-619; Coverage: 100%)
Gene names: GUC1B3, GUCSB3, GUCY1B1, GUCY1B3
Sequence domains:

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-9883
Expression system: Spodoptera frugiperda