Function and Biology Details
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Immunoglobulin C1-set
- MHC class I alpha chain, alpha1 alpha2 domains
- Beta-2-Microglobulin
- Immunoglobulin/major histocompatibility complex, conserved site
- Immunoglobulin-like domain superfamily
- Immunoglobulin-like domain
- Immunoglobulin-like fold
- MHC class I-like antigen recognition-like superfamily
2 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-133996 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, C alpha chain
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 31.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
Sequence domains:
Length: 273 amino acids
Theoretical weight: 31.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
- Canonical:
P10321 (Residues: 26-298; Coverage: 80%)
Sequence domains:
Beta-2-microglobulin
Molecule details ›
Chain: B
Length: 98 amino acids
Theoretical weight: 11.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
Sequence domains: Immunoglobulin C1-set domain
Length: 98 amino acids
Theoretical weight: 11.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
- Canonical: P61769 (Residues: 21-118; Coverage: 99%)
Sequence domains: Immunoglobulin C1-set domain
GTPase KRas, N-terminally processed
Molecule details ›
Chain: C
Length: 10 amino acids
Theoretical weight: 875 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 10 amino acids
Theoretical weight: 875 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P01116 (Residues: 10-19; Coverage: 5%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRF BEAMLINE BL17U1
Spacegroup:
P212121
Expression systems:
- Escherichia coli K-12
- Not provided
