› 6jtz

X-ray diffraction
2.8Å resolution

Crystal Structure of hRecQ1_D2-Zn-WH containing mutation on beta-hairpin

Released:
DOI: 10.2210/pdb6jtz/pdb
PDB entry 6jtz coloured by chain, front view.
PDB entry 6jtz coloured by chain, side view.
PDB entry 6jtz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Residues at the interface between zinc binding and winged helix domains of human RECQ1 play a significant role in DNA strand annealing activity.
Mukhopadhyay S, Das T, Bose M, Jain CK, Chakraborty M, Mukherjee S, Shikha K, Das AK, Ganguly A
Nucleic Acids Res 49 11834-11854 (2021)
PMID: 34751402

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent DNA helicase Q1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 352 amino acids
Theoretical weight: 40.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46063 (Residues: 282-616; Coverage: 51%)
Gene names: RECQ1, RECQL, RECQL1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 52.95Å b: 101.835Å c: 73.434Å
α: 90° β: 99.07° γ: 90°
R-values:
R R work R free
0.229 0.226 0.282
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Redox signaling at the crossroads of human health and disease.
Zuo et al. (2022)
1 other article

1 mention without citation

Residues at the interface between zinc binding and winged helix domains of human RECQ1 play a significant role in DNA strand annealing activity.
Mukhopadhyay et al. (2021)