› 6jvy

X-ray diffraction
2Å resolution

Crystal structure of RBM38 in complex with single-stranded DNA

Released:
DOI: 10.2210/pdb6jvy/pdb
PDB entry 6jvy coloured by chain, front view.
PDB entry 6jvy coloured by chain, side view.
PDB entry 6jvy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for mRNA recognition by human RBM38.
Qian K, Li M, Wang J, Zhang M, Wang M
Biochem J 477 161-172 (2020)
PMID: 31860021

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-120102 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
RNA-binding protein 38 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 13.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H0Z9 (Residues: 26-121; Coverage: 40%)
Gene names: RBM38, RNPC1, SEB4
Sequence domains: RNA recognition motif
DNA (5'-D(*TP*GP*TP*GP*TP*GP*TP*GP*TP*GP*TP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 12 nucleotides
Theoretical weight: 3.76 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3121
Unit cell:
a: 79.284Å b: 79.284Å c: 66.388Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.173 0.171 0.206
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

RNA-Binding Protein Rbm24 as a Multifaceted Post-Transcriptional Regulator of Embryonic Lineage Differentiation and Cellular Homeostasis.
Grifone et al. (2020)
1 more