› 6jyn

X-ray diffraction
1.6Å resolution

GII.13/21 noroviruses recognize glycans with a terminal beta-galactose via an unconventional glycan binding site

Released:
DOI: 10.2210/pdb6jyn/pdb
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PDB entry 6jyn coloured by chain, front view.
PDB entry 6jyn coloured by chain, side view.
PDB entry 6jyn coloured by chain, top view.
Source organism: Alphatron virus
Primary publication:
GII.13/21 Noroviruses Recognize Glycans with a Terminal β-Galactose via an Unconventional Glycan Binding Site.
Cong X, Sun XM, Qi JX, Li HB, Chai WG, Zhang Q, Wang H, Kong XY, Song J, Pang LL, Jin M, Li DD, Tan M, Duan ZJ
OpenAccess logo J Virol 93 (2019)
PMID: 31118252

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105284 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
human norovirus P domain protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 309 amino acids
Theoretical weight: 33.86 KDa
Source organism: Alphatron virus
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: A0A509GV45 (Residues: 1-309; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 69.936Å b: 122.935Å c: 83.28Å
α: 90° β: 90.07° γ: 90°
R-values:
R R work R free
0.186 0.181 0.201
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4

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Citations

2 citation in other articles

Structural basis of host ligand specificity change of GII porcine noroviruses from their closely related GII human noroviruses.
Yang et al. (2019)
1 more

1 mention without citation

GII.13/21 Noroviruses Recognize Glycans with a Terminal β-Galactose via an Unconventional Glycan Binding Site.
Cong et al. (2019)

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