› 6kd0

X-ray diffraction
1.8Å resolution

Crystal Structure of Vibralactone Cyclase

Released:
DOI: 10.2210/pdb6kd0/pdb
PDB entry 6kd0 coloured by chain, front view.
PDB entry 6kd0 coloured by chain, side view.
PDB entry 6kd0 coloured by chain, top view.
Source organism: Boreostereum vibrans
Primary publication:
A Hydrolase-Catalyzed Cyclization Forms the Fused Bicyclic β-Lactone in Vibralactone.
Feng KN, Yang YL, Xu YX, Zhang Y, Feng T, Huang SX, Liu JK, Zeng Y
Angew Chem Int Ed Engl 59 7209-7213 (2020)
PMID: 32050043

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166964 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vibralactone Cyclase Chain: A
Molecule details ›
Chain: A
Length: 343 amino acids
Theoretical weight: 38.72 KDa
Source organism: Boreostereum vibrans
Expression system: Escherichia coli BL21

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P21
Unit cell:
a: 47.324Å b: 80.234Å c: 59.184Å
α: 90° β: 102.36° γ: 90°
R-values:
R R work R free
0.18 0.18 0.199
Expression system: Escherichia coli BL21

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Citations

2 review citations

Genome mining methods to discover bioactive natural products.
Bauman et al. (2021)
1 more