Function and Biology Details
Reaction catalysed:
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Isocitrate dehydrogenase [NAD] mitochondrial (preferred)
PDBe Complex ID:
PDB-CPX-129150 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Molecule details ›
Chains: A, B, E, G, I, K, M, O
Length: 341 amino acids
Theoretical weight: 36.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Isocitrate/isopropylmalate dehydrogenase
Length: 341 amino acids
Theoretical weight: 36.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P50213 (Residues: 28-366; Coverage: 93%)
Sequence domains: Isocitrate/isopropylmalate dehydrogenase
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Molecule details ›
Chains: C, D, F, H, J, L, N, P
Length: 356 amino acids
Theoretical weight: 39.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Isocitrate/isopropylmalate dehydrogenase
Length: 356 amino acids
Theoretical weight: 39.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: O43837 (Residues: 35-374; Coverage: 88%)
Sequence domains: Isocitrate/isopropylmalate dehydrogenase
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRF BEAMLINE BL19U1
Spacegroup:
C2
Expression system: Escherichia coli
