› 6kln

Electron Microscopy
3.4Å resolution

F-actin of cardiac thin filament in high-calcium state

Released:
DOI: 10.2210/pdb6kln/pdb
PDB entry 6kln coloured by chain, front view.
PDB entry 6kln coloured by chain, side view.
PDB entry 6kln coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.
Oda T, Yanagisawa H, Wakabayashi T
J Struct Biol 209 107450 (2020)
PMID: 31954841
Related structures: EMD-0712

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 375 amino acids
Theoretical weight: 41.88 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P68134 (Residues: 3-377; Coverage: 100%)
Gene names: Acta, Acta1
Sequence domains: Actin

Ligands and Environments

2 bound ligands:
Ligand MG 4 x MG
Ligand ADP 4 x ADP
1 modified residue:
Ligand HIC 4 x HIC

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-0712

Quick links

Citations

2 review citations

50 Years of the steric-blocking mechanism in vertebrate skeletal muscle: a retrospective.
Parry DAD. (2023)
1 more

1 mention without citation

Structural insights into actin isoforms.
Arora et al. (2023)