› 6klu

Electron Microscopy
12Å resolution

Troponin of cardiac thin filament in high-calcium state

Released:
DOI: 10.2210/pdb6klu/pdb
PDB entry 6klu coloured by chain, front view.
PDB entry 6klu coloured by chain, side view.
PDB entry 6klu coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.
Oda T, Yanagisawa H, Wakabayashi T
J Struct Biol 209 107450 (2020)
PMID: 31954841
Related structures: EMD-0718

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148507 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Troponin C, slow skeletal and cardiac muscles Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 18.02 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P19123 (Residues: 2-158; Coverage: 98%)
Gene names: Tncc, Tnnc1
Sequence domains:
Troponin T, cardiac muscle Chain: B
Molecule details ›
Chain: B
Length: 74 amino acids
Theoretical weight: 9.09 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P50752 (Residues: 212-285; Coverage: 25%)
Gene name: Tnnt2
Sequence domains: Troponin
Troponin I, cardiac muscle Chain: C
Molecule details ›
Chain: C
Length: 118 amino acids
Theoretical weight: 13.81 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P48787 (Residues: 50-167; Coverage: 56%)
Gene name: Tnni3
Sequence domains: Troponin

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 12Å
Relevant EMDB volumes: EMD-0718

Quick links

Citations

2 review citations

Troponin Revealed: Uncovering the Structure of the Thin Filament On-Off Switch in Striated Muscle.
Tobacman LS. (2021)
1 more