6kmr

X-ray diffraction
2Å resolution

Crystal structure of human N6amt1-Trm112 in complex with SAM (space group P6122)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-193774 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Multifunctional methyltransferase subunit TRM112-like protein Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q9UI30 (Residues: 1-125; Coverage: 100%)
Gene names: AD-001, HSPC152, HSPC170, TRMT112
Sequence domains: Trm112p-like protein
Methyltransferase N6AMT1 Chain: B
Molecule details ›
Chain: B
Length: 228 amino acids
Theoretical weight: 24.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q9Y5N5 (Residues: 1-214; Coverage: 100%)
Gene names: C21orf127, HEMK2, KMT9, N6AMT1, PRED28
Sequence domains: Methyltransferase small domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P6122
Unit cell:
a: 109.708Å b: 109.708Å c: 130.786Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.163 0.162 0.192
Expression system: Escherichia coli K-12