Function and Biology Details
Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Proliferating cell nuclear antigen, PCNA
- DNA clamp superfamily
- DNA polymerase II large subunit DP2
- Proliferating cell nuclear antigen, PCNA, C-terminal
- Proliferating cell nuclear antigen, PCNA, conserved site
- Proliferating cell nuclear antigen, PCNA, N-terminal
- DNA polymerase II small subunit, archaeal
- DNA polymerase II large subunit DP2, N-terminal
4 more domains
Structure analysis Details
Assembly composition:
hetero heptamer (preferred)
PDBe Complex ID:
PDB-CPX-120162 (preferred)
Entry contents:
3 distinct polypeptide molecules
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (5 distinct):
DNA polymerase II small subunit
Molecule details ›
Chain: A
Length: 537 amino acids
Theoretical weight: 60.77 KDa
Source organism: Thermococcus kodakarensis KOD1
Expression system: Escherichia coli
UniProt:
Sequence domains: DNA polymerase alpha/epsilon subunit B
Length: 537 amino acids
Theoretical weight: 60.77 KDa
Source organism: Thermococcus kodakarensis KOD1
Expression system: Escherichia coli
UniProt:
- Canonical:
Q5JET1 (Residues: 259-735; Coverage: 65%)
Sequence domains: DNA polymerase alpha/epsilon subunit B
DNA polymerase II large subunit, 1st part
Molecule details ›
Chain: B
Length: 1324 amino acids
Theoretical weight: 150.42 KDa
Source organism: Thermococcus kodakarensis
Expression system: Escherichia coli
UniProt:
Sequence domains: DNA polymerase II large subunit DP2
Length: 1324 amino acids
Theoretical weight: 150.42 KDa
Source organism: Thermococcus kodakarensis
Expression system: Escherichia coli
UniProt:
- Canonical: Q5JET0 (Residues: 1-1798; Coverage: 74%)
Sequence domains: DNA polymerase II large subunit DP2
DNA polymerase sliding clamp 1
Molecule details ›
Chains: C, D, E
Length: 249 amino acids
Theoretical weight: 28.27 KDa
Source organism: Thermococcus kodakarensis KOD1
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 249 amino acids
Theoretical weight: 28.27 KDa
Source organism: Thermococcus kodakarensis KOD1
Expression system: Escherichia coli
UniProt:
- Canonical: Q5JF32 (Residues: 1-249; Coverage: 100%)
Sequence domains:
