› 6koi

X-ray diffraction
3.5Å resolution

Crystal structure of SNX11-PXe domain in dimer form.

Released:
DOI: 10.2210/pdb6koi/pdb
PDB entry 6koi coloured by chain, front view.
PDB entry 6koi coloured by chain, side view.
PDB entry 6koi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular Basis for PI(3,5)P2 Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation.
Xu T, Gan Q, Wu B, Yin M, Xu J, Shu X, Liu J
J Mol Biol 432 4750-4761 (2020)
PMID: 32561432

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195296 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorting nexin-11 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Length: 160 amino acids
Theoretical weight: 18.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5W9 (Residues: 7-158; Coverage: 56%)
Gene name: SNX11
Sequence domains: PX domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 72 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 142.04Å b: 190.434Å c: 237.012Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.234 0.265
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Transmembrane Membrane Readers form a Novel Class of Proteins That Include Peripheral Phosphoinositide Recognition Domains and Viral Spikes.
Overduin et al. (2022)
1 more

2 mentions without citation

Novel M2 -selective, Gi -biased agonists of muscarinic acetylcholine receptors.
Randáková et al. (2020)
1 more