› 6koj

X-ray diffraction
2.14Å resolution

Crystal structure of SNX11-PXe domain in complex with PI(3,5)P2

Released:
DOI: 10.2210/pdb6koj/pdb
PDB entry 6koj coloured by chain, front view.
PDB entry 6koj coloured by chain, side view.
PDB entry 6koj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular Basis for PI(3,5)P2 Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation.
Xu T, Gan Q, Wu B, Yin M, Xu J, Shu X, Liu J
J Mol Biol 432 4750-4761 (2020)
PMID: 32561432

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195294 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorting nexin-11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 144 amino acids
Theoretical weight: 16.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5W9 (Residues: 7-142; Coverage: 50%)
Gene name: SNX11
Sequence domains: PX domain

Ligands and Environments

1 bound ligand:
Ligand I35 2 x I35
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P1
Unit cell:
a: 31.86Å b: 45.27Å c: 50.48Å
α: 110.19° β: 106.04° γ: 90.07°
R-values:
R R work R free
0.205 0.201 0.271
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Transmembrane Membrane Readers form a Novel Class of Proteins That Include Peripheral Phosphoinositide Recognition Domains and Viral Spikes.
Overduin et al. (2022)
1 more

1 mention without citation

Regulation of the Phosphoinositide Code by Phosphorylation of Membrane Readers.
Kervin et al. (2021)