› 6kok

X-ray diffraction
2Å resolution

Crystal Structure of SNX11/SNX10-PXe Chimera

Released:
DOI: 10.2210/pdb6kok/pdb
PDB entry 6kok coloured by chain, front view.
PDB entry 6kok coloured by chain, side view.
PDB entry 6kok coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular Basis for PI(3,5)P2 Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation.
Xu T, Gan Q, Wu B, Yin M, Xu J, Shu X, Liu J
J Mol Biol 432 4750-4761 (2020)
PMID: 32561432

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195293 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorting nexin-10; Sorting nexin-11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 160 amino acids
Theoretical weight: 18.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5X0 (Residues: 1-1, 135-153; Coverage: 10%)
  • Canonical: Q9Y5W9 (Residues: 8-139; Coverage: 49%)
Gene names: SNX10, SNX11
Sequence domains: PX domain

Ligands and Environments

2 bound ligands:
Ligand CL 13 x CL
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 40.103Å b: 47.91Å c: 87.309Å
α: 90° β: 94.39° γ: 90°
R-values:
R R work R free
0.206 0.204 0.25
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Transmembrane Membrane Readers form a Novel Class of Proteins That Include Peripheral Phosphoinositide Recognition Domains and Viral Spikes.
Overduin et al. (2022)
1 more