› 6kor

X-ray diffraction
2.6Å resolution

Crystal structure of the RRM domain of SYNCRIP

Released:
DOI: 10.2210/pdb6kor/pdb
PDB entry 6kor coloured by chain, front view.
PDB entry 6kor coloured by chain, side view.
PDB entry 6kor coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
SYNCRIP, a new player in pri-let-7a processing.
Chen Y, Chan J, Chen W, Li J, Sun M, Kannan GS, Mok YK, Yuan YA, Jobichen C
RNA 26 290-305 (2020)
PMID: 31907208

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130009 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterogeneous nuclear ribonucleoprotein Q Chain: A
Molecule details ›
Chain: A
Length: 193 amino acids
Theoretical weight: 22.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60506 (Residues: 242-428; Coverage: 30%)
Gene names: HNRPQ, NSAP1, SYNCRIP
Sequence domains: RNA recognition motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: R3
Unit cell:
a: 103.634Å b: 103.634Å c: 49.289Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.182 0.25
Expression system: Escherichia coli

Quick links

Citations

3 review citations

let-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation.
Bernstein et al. (2021)
2 more

2 mentions without citation

SYNCRIP, a new player in pri-let-7a processing.
Chen et al. (2020)
1 more