› 6kp6

X-ray diffraction
3Å resolution

The structural study of mutation induced inactivation of Human muscarinic receptor M4

Released:
DOI: 10.2210/pdb6kp6/pdb
PDB entry 6kp6 coloured by chain, front view.
PDB entry 6kp6 coloured by chain, side view.
PDB entry 6kp6 coloured by chain, top view.
Source organisms:
Primary publication:
The structural study of mutation-induced inactivation of human muscarinic receptor M4
Wang JJ, Wu M, Wu LJ, Xu Y, Li F, Wu Y, Popov P, Wang L, Bai F, Zhao S, Liu ZJ, Hua T
IUCrJ 7 294-305 (2020)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139964 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Muscarinic acetylcholine receptor M4; Starch synthase catalytic domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 492 amino acids
Theoretical weight: 55.44 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08173 (Residues: 22-227, 390-479; Coverage: 62%)
  • Canonical: Q9V2J8 (Residues: 218-413; Coverage: 45%)
Gene names: CHRM4, PAB2292
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 56.1Å b: 61.32Å c: 203.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.231 0.264
Expression system: Spodoptera frugiperda

Quick links