› 6krd

Electron Microscopy
4.38Å resolution

TRiC at 0.05 mM ADP-AlFx, Conformation 4, 0.05-C4

Released:
DOI: 10.2210/pdb6krd/pdb
PDB entry 6krd coloured by chain, front view.
PDB entry 6krd coloured by chain, side view.
PDB entry 6krd coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Jin M, Han W, Liu C, Zang Y, Li J, Wang F, Wang Y, Cong Y
Proc Natl Acad Sci U S A 116 19513-19522 (2019)
PMID: 31492816
Related structures: EMD-0756

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146270 (preferred)
Entry contents:
8 distinct polypeptide molecules
Macromolecules (8 distinct):
T-complex protein 1 subunit alpha Chains: A, a
Molecule details ›
Chains: A, a
Length: 559 amino acids
Theoretical weight: 60.56 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P12612 (Residues: 1-559; Coverage: 100%)
Gene names: CCT1, TCP1, YD8142.13, YD8142B.04, YDR212W
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit beta Chains: B, b
Molecule details ›
Chains: B, b
Length: 527 amino acids
Theoretical weight: 57.28 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P39076 (Residues: 1-527; Coverage: 100%)
Gene names: BIN3, CCT2, TCP2, YIL142W
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit delta Chains: D, d
Molecule details ›
Chains: D, d
Length: 528 amino acids
Theoretical weight: 57.68 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P39078 (Residues: 1-528; Coverage: 100%)
Gene names: ANC2, CCT4, TCP4, YDL143W
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit epsilon Chains: E, e
Molecule details ›
Chains: E, e
Length: 562 amino acids
Theoretical weight: 62 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P40413 (Residues: 1-562; Coverage: 100%)
Gene names: CCT5, J1752, TCP5, YJR064W
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit gamma Chains: G, g
Molecule details ›
Chains: G, g
Length: 534 amino acids
Theoretical weight: 58.89 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P39077 (Residues: 1-534; Coverage: 100%)
Gene names: BIN2, CCT3, J1336, TCP3, YJL014W
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit theta Chains: Q, q
Molecule details ›
Chains: Q, q
Length: 568 amino acids
Theoretical weight: 61.74 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P47079 (Residues: 1-568; Coverage: 100%)
Gene names: CCT8, J1374, YJL008C
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit zeta Chains: Z, z
Molecule details ›
Chains: Z, z
Length: 546 amino acids
Theoretical weight: 60 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P39079 (Residues: 1-546; Coverage: 100%)
Gene names: CCT6, TCP20, TCP6, YD9395.21, YDR188W
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit eta Chains: H, h
Molecule details ›
Chains: H, h
Length: 550 amino acids
Theoretical weight: 59.8 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P42943 (Residues: 1-550; Coverage: 100%)
Gene names: CCT7, J0804, YJL111W
Sequence domains: TCP-1/cpn60 chaperonin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.38Å
Relevant EMDB volumes: EMD-0756

Quick links

Citations

5 review citations

The structural basis of T-cell receptor (TCR) activation: An enduring enigma.
Mariuzza et al. (2020)
4 more

1 mention without citation

An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Jin et al. (2019)