› 6ks0

X-ray diffraction
2.79Å resolution

Crystal structure of the human adiponectin receptor 1

Released:
DOI: 10.2210/pdb6ks0/pdb
PDB entry 6ks0 coloured by chain, front view.
PDB entry 6ks0 coloured by chain, side view.
PDB entry 6ks0 coloured by chain, top view.
Source organisms:
Primary publication:
Human adiponectin receptor AdipoR1 assumes closed and open structures.
Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Kano K, Kawana H, Hato M, Nakamura Y, Terada T, Kimura-Someya T, Shirouzu M, Kawano Y, Yamamoto M, Aoki J, Yamauchi T, Kadowaki T, Yokoyama S
Commun Biol 3 446 (2020)
PMID: 32796916

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212681 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Adiponectin receptor protein 1 Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 35.04 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96A54 (Residues: 89-375; Coverage: 77%)
Gene names: ADIPOR1, CGI-45, PAQR1, TESBP1A
Sequence domains: Haemolysin-III related
The heavy chain variable domain (Antibody) Chain: H
Molecule details ›
Chain: H
Length: 119 amino acids
Theoretical weight: 13.16 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
The light chain variable domain (Antibody) Chain: L
Molecule details ›
Chain: L
Length: 107 amino acids
Theoretical weight: 11.65 KDa
Source organism: Mus musculus
Expression system: Escherichia coli

Ligands and Environments

2 bound ligands:
Ligand PO4 1 x PO4
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: C2221
Unit cell:
a: 92.663Å b: 194.443Å c: 74.384Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.221 0.277
Expression systems:
  • Trichoplusia ni
  • Escherichia coli

Quick links

Citations

5 review citations

Sphingolipids in metabolic disease: The good, the bad, and the unknown.
Green et al. (2021)
4 more

2 mentions without citation

Human adiponectin receptor AdipoR1 assumes closed and open structures.
Tanabe et al. (2020)
1 more