› 6ksw

Electron Microscopy
3.6Å resolution

Cryo-EM structure of the human concentrative nucleoside transporter CNT3

Released:
DOI: 10.2210/pdb6ksw/pdb
PDB entry 6ksw coloured by chain, front view.
PDB entry 6ksw coloured by chain, side view.
PDB entry 6ksw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of the human concentrative nucleoside transporter CNT3.
Zhou Y, Liao L, Wang C, Li J, Chi P, Xiao Q, Liu Q, Guo L, Sun L, Deng D
PLoS Biol 18 e3000790 (2020)
PMID: 32776918
Related structures: EMD-0775

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190723 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 28 member 3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 632 amino acids
Theoretical weight: 70.37 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9HAS3 (Residues: 70-691; Coverage: 90%)
Gene names: CNT3, SLC28A3
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-0775
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

A Historical Review of Brain Drug Delivery.
Pardridge WM. (2022)
4 more

1 mention without citation

Structure Reveals Homology in Elevator Transporters.
Trebesch et al. (2023)