› 6kuw

X-ray diffraction
2.8Å resolution

Crystal structure of human alpha2C adrenergic G protein-coupled receptor.

Released:
DOI: 10.2210/pdb6kuw/pdb
PDB entry 6kuw coloured by chain, front view.
PDB entry 6kuw coloured by chain, side view.
PDB entry 6kuw coloured by chain, top view.
Source organisms:
Entry authors: Chen XY, Wu LJ, Wu D, Zhong GS

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148450 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-2C adrenergic receptor; Starch synthase catalytic domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 496 amino acids
Theoretical weight: 55.51 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P18825 (Residues: 29-241, 372-458; Coverage: 65%)
  • Canonical: Q9V2J8 (Residues: 218-413; Coverage: 45%)
Gene names: ADRA2C, ADRA2L2, ADRA2RL2, PAB2292
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand E33 2 x E33
Ligand CLR 2 x CLR
Ligand OLC 7 x OLC
Ligand OLA 2 x OLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 74.48Å b: 78.74Å c: 190.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.262
Expression system: Spodoptera frugiperda

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