› 6kux

X-ray diffraction
2.7Å resolution

Crystal structures of the alpha2A adrenergic receptor in complex with an antagonist RSC.

Released:
DOI: 10.2210/pdb6kux/pdb
PDB entry 6kux coloured by chain, front view.
PDB entry 6kux coloured by chain, side view.
PDB entry 6kux coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Qu L, Zhou QT, Wu D, Zhao SW

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140425 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-2A adrenergic receptor Chain: A
Molecule details ›
Chain: A
Length: 395 amino acids
Theoretical weight: 44.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08913 (Residues: 35-334, 335-379, 380-460; Coverage: 84%)
Gene names: ADRA2A, ADRA2R, ADRAR
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

4 bound ligands:
Ligand E3F 1 x E3F
Ligand PEG 5 x PEG
Ligand OLA 1 x OLA
Ligand FLC 1 x FLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2221
Unit cell:
a: 71.17Å b: 71.79Å c: 284.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.251 0.267
Expression system: Spodoptera frugiperda

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