› 6kvm

X-ray diffraction
1.9Å resolution

Crystal structure of Chicken MHC Class II for 1.9 angstrom

Released:
DOI: 10.2210/pdb6kvm/pdb
PDB entry 6kvm coloured by chain, front view.
PDB entry 6kvm coloured by chain, side view.
PDB entry 6kvm coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
A Newly Recognized Pairing Mechanism of the α- and β-Chains of the Chicken Peptide-MHC Class II Complex.
Zhang L, Li X, Ma L, Zhang B, Meng G, Xia C
J Immunol 204 1630-1640 (2020)
PMID: 32034060

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159255 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 22.13 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4U5Z6 (Residues: 24-217; Coverage: 83%)
Gene name: B-LA
Sequence domains:
Ig-like domain-containing protein Chain: B
Molecule details ›
Chain: B
Length: 214 amino acids
Theoretical weight: 24.11 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4U600 (Residues: 27-224; Coverage: 84%)
Gene names: B-LB, BLB2
Sequence domains:
Large ribosomal subunit protein eL30 Chain: C
Molecule details ›
Chain: C
Length: 17 amino acids
Theoretical weight: 1.89 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P67883 (Residues: 99-115; Coverage: 15%)
Gene name: RPL30

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: C2
Unit cell:
a: 152.397Å b: 57.297Å c: 58.057Å
α: 90° β: 110.676° γ: 90°
R-values:
R R work R free
0.204 0.203 0.227
Expression system: Escherichia coli

Quick links

Citations

7 citation in other articles

Identification of Novel T-Cell Epitopes on Infectious Bronchitis Virus N Protein and Development of a Multi-epitope Vaccine.
Qin et al. (2021)
6 more

4 mentions without citation

New vistas unfold: Chicken MHC molecules reveal unexpected ways to present peptides to the immune system.
Halabi et al. (2022)
3 more