› 6kwx

Electron Microscopy
3.75Å resolution

cryo-EM structure of human PA200

Released:
DOI: 10.2210/pdb6kwx/pdb
PDB entry 6kwx coloured by chain, front view.
PDB entry 6kwx coloured by chain, side view.
PDB entry 6kwx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures.
Guan H, Wang Y, Yu T, Huang Y, Li M, Saeed AFUH, Perčulija V, Li D, Xiao J, Wang D, Zhu P, Ouyang S
PLoS Biol 18 e3000654 (2020)
PMID: 32134919
Related structures: EMD-0780

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172136 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proteasome activator complex subunit 4 Chain: A
Molecule details ›
Chain: A
Length: 1878 amino acids
Theoretical weight: 215.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14997 (Residues: 1-1843; Coverage: 100%)
Gene names: KIAA0077, PSME4
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand K0W 1 x K0W
Ligand IHP 1 x IHP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.75Å
Relevant EMDB volumes: EMD-0780
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Role of Inositols and Inositol Phosphates in Energy Metabolism.
Chatree et al. (2020)
6 more

4 mentions without citation

The proteasome and its role in the nervous system.
Türker et al. (2021)
3 more