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› 6kx2

X-ray diffraction
1.45Å resolution

Crystal structure of GDP bound RhoA protein

Released:
DOI: 10.2210/pdb6kx2/pdb
Model geometry
Fit model/data
PDB entry 6kx2 coloured by chain, front view.
PDB entry 6kx2 coloured by chain, side view.
PDB entry 6kx2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.
Sun Z, Zhang H, Zhang Y, Liao L, Zhou W, Zhang F, Lian F, Huang J, Xu P, Zhang R, Lu W, Zhu M, Tao H, Yang F, Ding H, Chen S, Yue L, Zhou B, Zhang N, Tan M, Jiang H, Chen K, Liu B, Liu C, Dang Y, Luo C
OpenAccess logo Adv Sci (Weinh) 7 2000098 (2020)
PMID: 32714746

Function and Biology Details

Reaction catalysed: 
GTP + H2O = GDP + phosphate + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158275 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transforming protein RhoA Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 20.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61586 (Residues: 1-181; Coverage: 94%)
Gene names: ARH12, ARHA, RHO12, RHOA
Sequence domains: Ras family

Ligands and Environments

1 bound ligand:
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P43212
Unit cell:
a: 91.819Å b: 91.819Å c: 56.861Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.21
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Targeting Small GTPases and Their Prenylation in Diabetes Mellitus.
Gendaszewska-Darmach et al. (2021)
3 more

2 mentions without citation

Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.
Sun et al. (2020)
1 more