6kxs

Electron Microscopy
3.4Å resolution

Cryo-EM structure of human IgM-Fc in complex with the J chain and the ectodomain of pIgR

Released:
Source organism: Homo sapiens
Primary publication:
Structural insights into immunoglobulin M.
Science 367 1014-1017 (2020)
PMID: 32029689
Related structures: EMD-0782

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-134431 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Immunoglobulin heavy constant mu Chains: A, B, C, D, E, F, G, H, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, K, L
Length: 383 amino acids
Theoretical weight: 41.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01871 (Residues: 106-433; Coverage: 69%)
Gene name: IGHM
Sequence domains: Immunoglobulin C1-set domain
Immunoglobulin J chain Chain: J
Molecule details ›
Chain: J
Length: 136 amino acids
Theoretical weight: 15.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01591 (Residues: 24-159; Coverage: 99%)
Gene names: IGCJ, IGJ, JCHAIN
Sequence domains: Immunoglobulin J chain
Secretory component Chain: P
Molecule details ›
Chain: P
Length: 555 amino acids
Theoretical weight: 61.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01833 (Residues: 19-565; Coverage: 73%)
Gene name: PIGR
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-0782
Expression system: Homo sapiens