› 6l0o

X-ray diffraction
1.21Å resolution

WH domain of human MCM8

Released:
DOI: 10.2210/pdb6l0o/pdb
PDB entry 6l0o coloured by chain, front view.
PDB entry 6l0o coloured by chain, side view.
PDB entry 6l0o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the winged-helix domain of MCM8.
Zeng H, Li J, Xu H, Li H, Liu Y
Biochem Biophys Res Commun 526 993-998 (2020)
PMID: 32295713

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193811 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA helicase MCM8 Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UJA3 (Residues: 770-840; Coverage: 9%)
Gene names: C20orf154, MCM8

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P61
Unit cell:
a: 52.062Å b: 52.062Å c: 50.468Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.122 0.12 0.146
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Molecular functions of MCM8 and MCM9 and their associated pathologies.
Helderman et al. (2023)