› 6l22

X-ray diffraction
2.12Å resolution

Crystal structure of CK2a1 H115Y with hematein

Released:
DOI: 10.2210/pdb6l22/pdb
Model geometry
Fit model/data
PDB entry 6l22 coloured by chain, front view.
PDB entry 6l22 coloured by chain, side view.
PDB entry 6l22 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights for producing CK2α1-specific inhibitors.
Tsuyuguchi M, Nakaniwa T, Hirasawa A, Nakanishi I, Kinoshita T
Bioorg Med Chem Lett 30 126837 (2020)
PMID: 31859160

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 40.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-335; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand E3U 1 x E3U
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 48.107Å b: 79.21Å c: 82.657Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.18 0.243
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Crystal structure of Arabidopsis thaliana casein kinase 2 α1.
Demulder et al. (2020)