› 6l6i

X-ray diffraction
3.24Å resolution

hASIC1a co-crystallized with Mamb-1

Released:
DOI: 10.2210/pdb6l6i/pdb
PDB entry 6l6i coloured by chain, front view.
PDB entry 6l6i coloured by chain, side view.
PDB entry 6l6i coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lei F, Jian S

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160250 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acid-sensing ion channel 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 454 amino acids
Theoretical weight: 51.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P78348 (Residues: 25-464; Coverage: 83%)
Gene names: ACCN2, ASIC1, BNAC2
Sequence domains: Amiloride-sensitive sodium channel

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P212121
Unit cell:
a: 80.92Å b: 146.62Å c: 207.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.25
Expression system: Spodoptera frugiperda

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