Function and Biology Details
Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
- Alpha/Beta hydrolase fold
- Spike S1 subunit, receptor binding domain superfamily, betacoronavirus
- Spike (S) protein S1 subunit, receptor-binding domain, MERS-CoV
- Peptidase S9, serine active site
- Peptidase S9, prolyl oligopeptidase, catalytic domain
- Dipeptidylpeptidase IV, N-terminal domain
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
Spike protein S2' and Dipeptidyl peptidase 4 (preferred)
PDBe Complex ID:
PDB-CPX-125686 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Dipeptidyl peptidase 4
Molecule details ›
Chains: A, C, E, G
Length: 731 amino acids
Theoretical weight: 84.65 KDa
Source organism: Myotis davidii
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 731 amino acids
Theoretical weight: 84.65 KDa
Source organism: Myotis davidii
Expression system: Trichoplusia ni
UniProt:
- Canonical:
L5LQ33 (Residues: 24-748; Coverage: 97%)
Sequence domains:
Spike protein S1
Molecule details ›
Chains: B, D, F, H
Length: 246 amino acids
Theoretical weight: 27.11 KDa
Source organism: Middle East respiratory syndrome-related coronavirus
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Length: 246 amino acids
Theoretical weight: 27.11 KDa
Source organism: Middle East respiratory syndrome-related coronavirus
Expression system: Trichoplusia ni
UniProt:
- Canonical: K9N5Q8 (Residues: 367-606; Coverage: 18%)
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
