› 6lat

Electron Microscopy
3.4Å resolution

The cryo-EM structure of HEV VLP

Released:
DOI: 10.2210/pdb6lat/pdb
PDB entry 6lat coloured by chain, front view.
PDB entry 6lat coloured by chain, side view.
PDB entry 6lat coloured by chain, top view.
Source organism: Orthohepevirus A
Primary publication:
Viral neutralization by antibody-imposed physical disruption.
Zheng Q, Jiang J, He M, Zheng Z, Yu H, Li T, Xue W, Tang Z, Ying D, Li Z, Song S, Liu X, Wang K, Zhang Z, Wang D, Wang Y, Yan X, Zhao Q, Zhang J, Gu Y, Li S, Xia N
Proc Natl Acad Sci U S A (2019)
PMID: 31818956
Related structures: EMD-0863

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152614 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Secreted protein ORF2 Chain: A
Molecule details ›
Chain: A
Length: 477 amino acids
Theoretical weight: 51.3 KDa
Source organism: Orthohepevirus A
Expression system: Escherichia coli
UniProt:
  • Canonical: P33426 (Residues: 129-605; Coverage: 74%)
Gene name: ORF2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-0863
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Antibodies to combat viral infections: development strategies and progress.
Pantaleo et al. (2022)
2 more

3 mentions without citation

Viral neutralization by antibody-imposed physical disruption.
Zheng et al. (2019)
2 more