› 6lcb

X-ray diffraction
1.4Å resolution

Crystal structure of human Dishevelled1 PDZ domain with its inhibitor NPL3009

Released:
DOI: 10.2210/pdb6lcb/pdb
Model geometry
Fit model/data
PDB entry 6lcb coloured by chain, front view.
PDB entry 6lcb coloured by chain, side view.
PDB entry 6lcb coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yasukochi S, Numoto N, Tenno N, Tenno T, Ito N, Hiroaki H

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127028 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Segment polarity protein dishevelled homolog DVL-1 Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 10.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14640 (Residues: 246-340; Coverage: 14%)
Gene name: DVL1
Sequence domains: PDZ domain

Ligands and Environments

2 bound ligands:
Ligand E83 1 x E83
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PHOTON FACTORY BEAMLINE BL-1A
Spacegroup: I4122
Unit cell:
a: 85.375Å b: 85.375Å c: 46.167Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.214 0.23
Expression system: Escherichia coli BL21(DE3)

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