› 6ldx

X-ray diffraction
1.8Å resolution

Structure antibody E6 in complex with methylated peptide

Released:
DOI: 10.2210/pdb6ldx/pdb
Model geometry
Fit model/data
PDB entry 6ldx coloured by chain, front view.
PDB entry 6ldx coloured by chain, side view.
PDB entry 6ldx coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for antigen recognition by methylated lysine-specific antibodies.
Ishii M, Nakakido M, Caaveiro JMM, Kuroda D, Okumura CJ, Maruyama T, Entzminger K, Tsumoto K
OpenAccess logo J Biol Chem 296 100176
PMID: 33303630

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212874 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 243 amino acids
Theoretical weight: 25.8 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 238 amino acids
Theoretical weight: 25.36 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
Mitogen-activated protein kinase kinase kinase 2 Chain: B

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
1 modified residue:
Ligand M3L 1 x M3L

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PHOTON FACTORY BEAMLINE BL-1A
Spacegroup: P41212
Unit cell:
a: 82.329Å b: 82.329Å c: 120.269Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.169 0.217
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

2 review citations

Epigenetics and Beyond: Targeting Histone Methylation to Treat Type 2 Diabetes Mellitus.
Yang et al. (2021)
1 more

1 mention without citation

Structural basis for antigen recognition by methylated lysine-specific antibodies.
Ishii et al. (2021)