› 6lgp

Electron Microscopy
3.3Å resolution

cryo-EM structure of TRPV3 in lipid nanodisc

Released:
DOI: 10.2210/pdb6lgp/pdb
PDB entry 6lgp coloured by chain, front view.
PDB entry 6lgp coloured by chain, side view.
PDB entry 6lgp coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism.
Shimada H, Kusakizako T, Dung Nguyen TH, Nishizawa T, Hino T, Tominaga M, Nureki O
Nat Struct Mol Biol 27 645-652 (2020)
PMID: 32572254
Related structures: EMD-0882

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185081 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 639 amino acids
Theoretical weight: 73.95 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8K424 (Residues: 118-756; Coverage: 81%)
Gene name: Trpv3
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand POV 16 x POV
Ligand PLC 12 x PLC
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-0882
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Structural Pharmacology of TRP Channels.
Zhao et al. (2021)
2 more

9 mentions without citation

Ligand-Binding Sites in Vanilloid-Subtype TRP Channels.
Yelshanskaya et al. (2022)
8 more