› 6lhu

Electron Microscopy
3.46Å resolution

High resolution structure of FANCA C-terminal domain (CTD)

Released:
DOI: 10.2210/pdb6lhu/pdb
PDB entry 6lhu coloured by chain, front view.
PDB entry 6lhu coloured by chain, side view.
PDB entry 6lhu coloured by chain, top view.
Source organism: Xenopus laevis
Primary publication:
Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex.
Jeong E, Lee SG, Kim HS, Yang J, Shin J, Kim Y, Kim J, Schärer OD, Kim Y, Yeo JE, Kim HM, Cho Y
Nucleic Acids Res 48 3328-3342 (2020)
PMID: 32002546
Related structures: EMD-0899

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175781 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fanconi anaemia group A protein N-terminal domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 1437 amino acids
Theoretical weight: 163.01 KDa
Source organism: Xenopus laevis
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q4VT51 (Residues: 1-1422; Coverage: 100%)
Gene names: FANCA, fa1, faa, faca, fanca, fanca.L, fanch, xFA, xfanca
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.46Å
Relevant EMDB volumes: EMD-0899
Expression system: Trichoplusia ni

Quick links

Citations

2 review citations

Fanconi anemia pathway as a prospective target for cancer intervention.
Liu et al. (2020)
1 more

1 mention without citation

Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex.
Jeong et al. (2020)