› 6lhw

Electron Microscopy
4.84Å resolution

Structure of N-terminal and C-terminal domains of FANCA

Released:
DOI: 10.2210/pdb6lhw/pdb
PDB entry 6lhw coloured by chain, front view.
PDB entry 6lhw coloured by chain, side view.
PDB entry 6lhw coloured by chain, top view.
Source organism: Xenopus laevis
Primary publication:
Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex.
Jeong E, Lee SG, Kim HS, Yang J, Shin J, Kim Y, Kim J, Schärer OD, Kim Y, Yeo JE, Kim HM, Cho Y
Nucleic Acids Res 48 3328-3342 (2020)
PMID: 32002546
Related structures: EMD-0901

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167019 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fanconi anemia complementation group A Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1400 amino acids
Theoretical weight: 119.16 KDa
Source organism: Xenopus laevis
Expression system: Trichoplusia ni

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.84Å
Relevant EMDB volumes: EMD-0901
Expression system: Trichoplusia ni

Quick links

Citations

2 review citations

Fanconi anemia pathway as a prospective target for cancer intervention.
Liu et al. (2020)
1 more

1 mention without citation

Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex.
Jeong et al. (2020)