› 6lpk

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine receptor A2a; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 447 amino acids
Theoretical weight: 49.97 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29274 (Residues: 2-208, 219-316; Coverage: 74%)
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
Gene names: ADORA2, ADORA2A, cybC
Sequence domains:

Ligands and Environments

12 bound ligands:
Ligand ZMA 1 x ZMA
Ligand NA 1 x NA
Ligand CLR 3 x CLR
Ligand D12 1 x D12
Ligand MYS 6 x MYS
Ligand HEX 1 x HEX
Ligand 8K6 3 x 8K6
Ligand D10 1 x D10
Ligand OCT 3 x OCT
Ligand UND 1 x UND
Ligand ER0 2 x ER0
Ligand TRD 4 x TRD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SACLA BEAMLINE BL3
Spacegroup: C2221
Unit cell:
a: 40.5Å b: 179.2Å c: 142.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.209
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update.
IJzerman et al. (2022)
4 other articles

5 mentions without citation

Molecular Simulations and Drug Discovery of Adenosine Receptors.
Wang et al. (2022)
4 more