› 6lr0

Electron Microscopy
3.5Å resolution

structure of human bile salt exporter ABCB11

Released:
DOI: 10.2210/pdb6lr0/pdb
PDB entry 6lr0 coloured by chain, front view.
PDB entry 6lr0 coloured by chain, side view.
PDB entry 6lr0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human bile salts exporter ABCB11.
Wang L, Hou WT, Chen L, Jiang YL, Xu D, Sun L, Zhou CZ, Chen Y
Cell Res 30 623-625 (2020)
PMID: 32203132
Related structures: EMD-31583, EMD-0956

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131895 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bile salt export pump Chain: U
Molecule details ›
Chain: U
Length: 1321 amino acids
Theoretical weight: 146.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O95342 (Residues: 1-1321; Coverage: 100%)
Gene names: ABCB11, BSEP
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-31583, EMD-0956
Expression system: Homo sapiens

Quick links

Citations

5 citation in other articles

Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion.
Goda et al. (2020)
4 more

9 mentions without citation

Structural and functional diversity calls for a new classification of ABC transporters.
Thomas et al. (2020)
8 more