› 6lra

X-ray diffraction
1.9Å resolution

The complex structure of PHF core domain peptide of tau and antibody's Fab domain.

Released:
DOI: 10.2210/pdb6lra/pdb
PDB entry 6lra coloured by chain, front view.
PDB entry 6lra coloured by chain, side view.
PDB entry 6lra coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the human tau PHF core domain VQIINK complexed with the Fab domain of monoclonal antibody Tau2r3.
Tsuchida T, Susa K, Kibiki T, Tsuchiya T, Miyamoto K, In Y, Minoura K, Taniguchi T, Ishida T, Tomoo K
FEBS Lett (2020)
PMID: 32282060

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210482 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 218 amino acids
Theoretical weight: 23.07 KDa
Source organism: Mus musculus
Fab Light Chain Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 23.75 KDa
Source organism: Mus musculus
Microtubule-associated protein tau Chain: C
Molecule details ›
Chain: C
Length: 6 amino acids
Theoretical weight: 715 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 592-597; Coverage: 1%)
Gene names: MAPT, MAPTL, MTBT1, TAU

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: Cu FINE FOCUS
Spacegroup: P212121
Unit cell:
a: 59.65Å b: 70.68Å c: 118.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.188 0.249
Expression system: Not provided

Quick links

Citations

1 mention without citation

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status.
Pinzi et al. (2023)