› 6lsq

X-ray diffraction
1.8Å resolution

Crystal structure of Echistatin, an RGD-containing short disintegrin

Released:
DOI: 10.2210/pdb6lsq/pdb
PDB entry 6lsq coloured by chain, front view.
PDB entry 6lsq coloured by chain, side view.
PDB entry 6lsq coloured by chain, top view.
Source organism: Echis carinatus
Primary publication:
Structural Insight into Integrin Recognition and Anticancer Activity of Echistatin.
Chen YC, Chang YT, Chen CY, Shiu JH, Cheng CH, Huang CH, Chen JF, Chuang WJ
Toxins (Basel) 12 (2020)
PMID: 33182321

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148041 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disintegrin echistatin Chains: A, B
Molecule details ›
Chains: A, B
Length: 51 amino acids
Theoretical weight: 5.71 KDa
Source organism: Echis carinatus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P17347 (Residues: 131-179; Coverage: 26%)
Sequence domains: Disintegrin

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE TPS 05A
Spacegroup: P3221
Unit cell:
a: 33.906Å b: 33.906Å c: 121.172Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.212 0.255
Expression system: Komagataella pastoris

Quick links

Citations

3 mentions without citation

The chemistry of snake venom and its medicinal potential.
Oliveira et al. (2022)
2 more