6lt0

Electron Microscopy
3.2Å resolution

cryo-EM structure of C9ORF72-SMCR8-WDR41

Released:
Source organism: Homo sapiens
Related structures: EMD-0966

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-186258 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
WD repeat-containing protein 41 Chains: A, D
Molecule details ›
Chains: A, D
Length: 459 amino acids
Theoretical weight: 51.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9HAD4 (Residues: 1-459; Coverage: 100%)
Gene names: MSTP048, WDR41
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide exchange protein SMCR8 Chains: B, E
Molecule details ›
Chains: B, E
Length: 937 amino acids
Theoretical weight: 105.15 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8TEV9 (Residues: 1-937; Coverage: 100%)
Gene name: SMCR8
Sequence domains: Vesicle coat protein involved in Golgi to plasma membrane transport
Guanine nucleotide exchange factor C9orf72 Chains: C, F
Molecule details ›
Chains: C, F
Length: 481 amino acids
Theoretical weight: 54.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96LT7 (Residues: 1-481; Coverage: 100%)
Gene names: C9orf72, DENND9, DENNL72
Sequence domains: C9orf72-like protein family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-0966
Expression system: Spodoptera frugiperda