› 6luq

X-ray diffraction
3.1Å resolution

Haloperidol bound D2 dopamine receptor structure inspired discovery of subtype selective ligands

Released:
DOI: 10.2210/pdb6luq/pdb
PDB entry 6luq coloured by chain, front view.
PDB entry 6luq coloured by chain, side view.
PDB entry 6luq coloured by chain, top view.
Source organisms:
Primary publication:
Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands.
Fan L, Tan L, Chen Z, Qi J, Nie F, Luo Z, Cheng J, Wang S
Nat Commun 11 1074 (2020)
PMID: 32103023

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112935 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
D(2) dopamine receptor; Endolysin Chain: A
Molecule details ›
Chain: A
Length: 430 amino acids
Theoretical weight: 48.88 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P14416 (Residues: 35-222, 367-443; Coverage: 60%)
  • Canonical: D9IEF7 (Residues: 2-162; Coverage: 98%)
Gene names: DRD2, T4Tp126, e
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand GMJ 1 x GMJ
Ligand OLA 4 x OLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 50.433Å b: 72.82Å c: 150.269Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.215 0.229
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
8 more

16 mentions without citation

Neuronal Dopamine D3 Receptors: Translational Implications for Preclinical Research and CNS Disorders.
Kiss et al. (2021)
15 more