› 6m1y

Electron Microscopy
3.2Å resolution

The overall structure of KCC3

Released:
DOI: 10.2210/pdb6m1y/pdb
PDB entry 6m1y coloured by chain, front view.
PDB entry 6m1y coloured by chain, side view.
PDB entry 6m1y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters.
Chi X, Li X, Chen Y, Zhang Y, Su Q, Zhou Q
Cell Res 31 482-484 (2021)
PMID: 33199848
Related structures: EMD-30049

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193768 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Solute carrier family 12 member 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1112 amino acids
Theoretical weight: 123.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UHW9 (Residues: 71-78, 79-90, 91-1150; Coverage: 94%)
Gene names: KCC3, SLC12A6
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand K 2 x K
Ligand CL 4 x CL
Ligand NAG 4 x NAG
1 modified residue:
Ligand TPO 4 x TPO

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-30049
Expression system: Homo sapiens

Quick links

Citations

6 review citations

High-Resolution Views and Transport Mechanisms of the NKCC1 and KCC Transporters.
Chew et al. (2021)
5 more

5 mentions without citation

Cation-coupled chloride cotransporters: chemical insights and disease implications.
Portioli et al. (2021)
4 more