› 6m5y

X-ray diffraction
1.38Å resolution

Structure of human galectin-1 tandem-repeat mutant with lactose

Released:
DOI: 10.2210/pdb6m5y/pdb
PDB entry 6m5y coloured by chain, front view.
PDB entry 6m5y coloured by chain, side view.
PDB entry 6m5y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and conformational stability of a galectin-1 tandem-repeat mutant with a short linker.
Nonaka Y, Ogawa T, Shoji H, Nishi N, Kamitori S, Nakamura T
Glycobiology 32 251-259 (2022)
PMID: 34735570

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140622 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Galectin-1 Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 29.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09382 (Residues: 1-135, 2-135; Coverage: 100%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: GAL, GLC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P21212
Unit cell:
a: 67.38Å b: 95.64Å c: 37.63Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.183 0.219
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 mention without citation

Pan-cancer structurome reveals overrepresentation of beta sandwiches and underrepresentation of alpha helical domains.
Medvedev et al. (2023)