› 6m6z

Electron Microscopy
5.9Å resolution

A de novo designed transmembrane nanopore, TMH4C4

Released:
DOI: 10.2210/pdb6m6z/pdb
PDB entry 6m6z coloured by chain, front view.
PDB entry 6m6z coloured by chain, side view.
PDB entry 6m6z coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Computational design of transmembrane pores.
Xu C, Lu P, Gamal El-Din TM, Pei XY, Johnson MC, Uyeda A, Bick MJ, Xu Q, Jiang D, Bai H, Reggiano G, Hsia Y, Brunette TJ, Dou J, Ma D, Lynch EM, Boyken SE, Huang PS, Stewart L, DiMaio F, Kollman JM, Luisi BF, Matsuura T, Catterall WA, Baker D
Nature 585 129-134 (2020)
PMID: 32848250
Related structures: EMD-30126

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167052 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TMH4C4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 203 amino acids
Theoretical weight: 23.46 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.9Å
Relevant EMDB volumes: EMD-30126
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Recent advances in de novo protein design: Principles, methods, and applications.
Pan et al. (2021)
19 more

2 mentions without citation

Improved protein structure prediction by deep learning irrespective of co-evolution information.
Xu et al. (2021)
1 more